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* **Targeted Therapy:** Targeted therapies are designed to target specific molecules or pathways involved in cancer cell growth and survival. For HER2-positive breast cancers, drugs like trastuzumab (Herceptin), pertuzumab (Perjeta), and trastuzumab deruxtecan (Enhertu) can effectively block the HER2 receptor, inhibiting cancer cell growth. Other targeted therapies, such as PI3K inhibitors (e.g., alpelisib) and CDK4/6 inhibitors (e.g., palbociclib, ribociclib, abemaciclib), may be used in combination with hormone therapy for certain types of hormone receptor-positive breast cancers.
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Moreover, **epigenetics** adds another layer of complexity to the genetic basis of schizophrenia. Epigenetic modifications, such as DNA methylation and histone modification, can alter gene expression without changing the underlying DNA sequence. These modifications can be influenced by environmental factors, such as stress and exposure to toxins, and may play a role in the development of schizophrenia. For example, epigenetic changes could alter the expression of genes involved in neurotransmitter signaling or synaptic plasticity, contributing to the neurobiological abnormalities associated with the disorder. So, it's not just about the genes you inherit, but also how those genes are expressed, which can be influenced by your environment.
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